1000 Bull Genomes Project

The project:

The 1000 Bull Genomes Project aims to provide, for the bovine research community, a large database for imputation of genetic variants for genomic prediction and genome wide association studies in all cattle breeds. The project aims to develop a resource to allow project partners to impute full genome sequence in bulls and cows that have been genotyped with SNP arrays. This could be used, for example, for improving the accuracy of genomic prediction, as well as in genome wide association studies interested in the identification of causal mutations.

Since its inception in 2012, the 1000 Bull Genomes Project has grown from 234 animals (3 breeds) and identifying 28.3 million genetic variants to more than 5,000 cattle (200+ breeds of Bos species) and identifying >155 million filtered variants (Run 8).

Latest publication: Hayes BJ, Daetwyler HD. 1000 Bull Genomes Project to Map Simple and Complex Genetic Traits in Cattle: Applications and Outcomes. Annu Rev Anim Biosci. 2019 Feb 15;7:89-102.

Download a presentation describing the project [9.4MB .pptx] by Dr Amanda Chamberlain (2019).

Joining the project:

To join Run 9 of the 1000 Bull Genomes Project you are required to contribute BAM and GVCF (GATK genomic VCF) files for a minimum of 50 animals sequenced at 10x coverage after quality control (or 500x equivalent), and be approved by the project steering committee. Data submission deadline for Run 9 is 31-Jan-2021.

Project resources for Run 9: